HLA-Assoziationen mit erhöhtem Krankheitsrisiko
(RR= Relatives Risiko, RR>1: erhöhtes Risiko)
| Erkrankung |
Antigen |
RR |
| Orthopädie/Rheumatologie |
|
|
| Ankylosierende Spondylitis (M. Bechterew) |
HLA-B27 |
87,4 |
| Urethro-okulo-artikuläres Syndrom (M. Reiter) |
HLA-B27 |
37,0 |
| Shigellen-Arthritis |
HLA-B27 |
20,7 |
| Salmonellen-Arthritis |
HLA-B27 |
17,6 |
| Yersinia-Arthritis |
HLA-B27 |
17,6 |
| Gonokokken-Arthritis |
HLA-B27 |
13,9 |
| Psoriasis arthropathica |
HLA-B27 |
4,0 |
| Rheumatoide Arthritis |
HLA-DR4 |
10,2 |
| |
|
|
| Endokrinologie |
|
|
| Diabetes mellitus, juv. Form |
HLA-DR3 |
5,8 |
| |
HLA-DR4 |
4,1 |
| 21-Hydroxylase-Defizienz |
HLA-B47 |
9,9 |
| |
HLA-B51 |
3,6 |
| M. Basedow |
HLA-DR3 |
6,0 |
| |
|
|
| Gastroenterologie, Leber, Niere |
|
|
| Hämochromatose |
HLA-A3 |
8,2 |
| Zöliakie (Glutenenteropathie) |
HLA-B8 |
11,0 |
| |
HLA-DR3 |
10,8 |
| |
HLA-DR7 |
11,9 |
| |
HLA-DR3 |
|
| |
+DR7 |
52,1 |
| Idiopathische membranöse Glomerulonephritis |
HLA-DR3 |
12,0 |
| IgA-Nephropathie |
HLA-DR4 |
4,0 |
| Goodpasture-Syndrom |
HLA-DR2 |
15,9 |
| |
|
|
| Neurologie |
|
|
| Multiple Sklerose |
HLA-DR2 |
4,1 |
| Myasthenia gravis |
HLA-DR3 |
2,9 |
| |
HLA-B8
| 3,0 |
| Narkolepsie |
HLA-DR15 |
130 |
| |
HLA-DQ6 |
150 |
| |
|
|
| Kollagenosen |
|
|
| System. Lupus |
HLA-DR3 |
5,8 |
| erythematodes Sjögren-Syndrom |
HLA-DR3 |
9,7 |
| |
|
|
| Dermatologie |
|
|
| Psoriasis vulgaris |
HLA-B13 |
4,7 |
| |
HLA-B17 |
4,7 |
| |
HLA-Cw6 |
13,3 |
| M. Behçet |
HLA-B51 |
6,3 |
| Pemphigus vulgaris |
HLA-DR4 |
14,4 |
| Dermatitis |
HLA-DR3 |
15,4 |
| herpetiformis |
HLA-B8 |
8,7 |
| |
|
|
| Andere Krankheiten |
|
|
| Akute Uveitis anterior |
HLA-B27 |
10,4 |
(modifiziert nach: Labor und Diagnose; Thomas, L., S. 884-885, 1998)
|